Ekuqaleni kuka-2025, abacwaningi baseNyuvesi yaseWashington naseBrigham kanye neSibhedlela Sabesifazane (isibhedlela sokufundisa sase-Harvard Medical School) baveze indlela engakaze ibonwe yokwelapha isifo i-Alzheimer's - ukuhogela umoya.xenonigesi, engavimbi kuphela i-neuroinflammation futhi inciphise i-atrophy yobuchopho, kodwa futhi yandisa izifunda ze-neuronal ezivikelayo.

I-Xenonkanye Neuroprotection

Isifo i-Alzheimer's yisifo esivame kakhulu se-neurodegenerative kubantu, futhi imbangela yaso kukholakala ukuthi ihlobene nokunqwabelana kwamaprotheni e-tau kanye ne-beta-amyloid ebuchosheni. Nakuba kuye kwaba nemithi ezama ukususa lamaprotheni anobuthi, ayizange iphumelele ekubambezeleni ukuqhubeka kwesifo. Ngakho-ke, akuqondwa ngokugcwele imbangela yalesi sifo noma indlela yokwelapha.

Ucwaningo luye lwabonisa ukuthi ukuhogelaxenoningawela umgoqo wegazi nobuchopho futhi ithuthukise kakhulu isimo samagundane ngamamodeli esifo i-Alzheimer's ngaphansi kwezimo zaselabhorethri.Ukuhlolwa kwahlukaniswa ngamaqembu amabili, iqembu elilodwa lamagundane libonise ukunqwabelana kwamaprotheni e-tau kanti elinye iqembu line-beta-amyloid protein accumulation. Imiphumela yokuhlola ibonise ukuthi i-xenon ayizange nje yenze amagundane asebenze kakhulu, kodwa futhi yakhuthaza ukusabela kokuvikela kwe-microglia, ebalulekile ekuhlanzeni amaprotheni e-tau nawe-beta-amyloid.

Lokhu kutholakala okusha kuyinoveli kakhulu, okubonisa ukuthi imiphumela ye-neuroprotective ingakhiqizwa ngokuhogela igesi engasebenzi. Umkhawulo omkhulu emkhakheni wocwaningo nokwelashwa kwe-Alzheimer ukuthi kunzima kakhulu ukuklama izidakamizwa ezingawela umgoqo wegazi nobuchopho, futhixenonangakwenza lokhu.

Ezinye izinhlelo zokusebenza zezokwelapha ze-xenon

1. I-Anesthesia kanye ne-analgesia: Njengegesi efanelekile yokubulala izinzwa,xenonisetshenziswa kabanzi ngenxa yokungeniswa kwayo ngokushesha nokululama, ukuzinza okuhle kwenhliziyo nemithambo yegazi kanye nengozi ephansi yemiphumela emibi;

2. Umphumela we-Neuroprotective: Ngaphezu komphumela wokwelapha ongase ube khona esifweni se-Alzheimer okukhulunywe ngaso ngenhla, i-xenon nayo iye yacwaningwa ukuze kuncishiswe ukulimala kobuchopho okubangelwa yi-neonatal hypoxic-ischemic encephalopathy (HIE);

3. Ukufakelwa izitho zomzimba kanye nokuvikelwa:I-Xenoningasiza ukuvikela izitho zabanikeli ekulimaleni kwe-ischemia-reperfusion, okubaluleke kakhulu ekuthuthukiseni izinga lokuphumelela lokufakelwa kabusha;

4. Ukuzwela kwe-Radiotherapy: Ezinye izifundo zokuqala zibonise ukuthi i-xenon ingase ikwazi ukuthuthukisa ukuzwela kwamathumba ku-radiotherapy, okunikeza isu elisha lokwelapha umdlavuza;