Ekuqaleni kuka-2025, abacwaningi abavela e-University of Washington nasesibhedlela sabesifazane kanye nabesifazane (isibhedlela sokufundisa saseHarvard Medical School) siveze indlela engakaze ibonwe ngecala lokuphatha izifo ze-Alzheimer - UkuphefumulaisixubhoIgesi, engavimba nje kuphela i-neuroinflammation futhi inciphise i-atrophy yobuchopho, kepha futhi ikhulisa izifundazwe ze-neuronal.

Isixubhokanye ne-neuroprotection

Isifo se-Alzheimer's yisifo esivame kakhulu se-neurodegenerative kubantu, futhi nenhloso yayo kukholakala ukuthi kuhlobene nokuqongelelwa kwamaprotheni e-tau kanye ne-beta-amyloid engqondweni. Yize kube nezidakamizwa ezizama ukususa la maprotheni anobuthi, aziphumelelanga ukwehlisa ukuqhubeka kwesifo. Ngakho-ke, noma izimpande zesifo noma ukwelashwa kuqondwe ngokuphelele.

Ucwaningo lukhombisile ukuthi u-inhalidisixubhoUngawela umgoqo wegazi-ubuchopho futhi uthuthukise kakhulu isimo samagundane anamamodeli wezifo ze-Alzheimer's ngaphansi kwezimo zelebhu.Isivivinyo sahlukaniswa saba ngamaqembu amabili, iqembu elilodwa lamagundane likhombise ukuqongelela amaprotheni tau kanye nelinye iqembu lalinenqwaba yeprotheni ye-beta-amyloid. Imiphumela yokuhlola ikhombisile ukuthi uXennon azange nje enze amagundane asebenze kakhulu, kodwa futhi akhuthaza futhi impendulo yokuvikela i-microglia, ebalulekile ekususeni amaprotheni e-tau kanye ne-beta-amyloid.

Lokhu okutholwe okusha kuyinoveli enkulu, okubonisa ukuthi imiphumela ye-inuvoprotaterict ingakhiqizwa ngokumane infining igesi e-inert. Umkhawulo omkhulu emkhakheni wocwaningo nokwelashwa kuka-Alzheimer's nokwelashwa ukuthi kunzima kakhulu ukuklama izidakamizwa ezikwazi ukunqamula isithiyo segazi-ubuchopho, futhiisixubhoungakwenza lokhu.

Ezinye izinhlelo zokusebenza zezokwelapha zeXENON

1. I-anesthesia ne-analgesia: njengegesi enhle kakhulu yokubulala izinzwa,isixubhoisetshenziswa kabanzi ngenxa yokungeniswa kwayo okusheshayo nokululama, ukuqina okuhle kwenhliziyo kanye nengozi ephansi yemiphumela emibi;

2. Umphumela we-Neuroprotactive: Ngaphezu kwethonya lezokwelapha elingaba khona ngesifo se-Alzheimer esishiwo ngenhla, i-XENON selifundwe nokunciphisa ukulimala kobuchopho okubangelwa yi-neonatal hypoxic-ischemic encephalopathy (HIE);

3. Ukufakelwa kanye nokuvikelwa:IsixubhoKwangathi kungasiza ukuvikela izitho zomzimba ezivela ekulimaleni kwe-Ischemia-ReperFusion, okubaluleke kakhulu ekuthuthukiseni izinga lokufakelwa kokufakelwa;

I-4. I-radiotherapy Studitization: Ezinye izifundo zokuqala zikhombise ukuthi i-XENONIMARIONS ingakwazi ukuthuthukisa ukuzwela kwamathumbu e-radiotherapy, okunikezela isu elisha lokwelashwa komdlavuza;