Ekuqaleni kuka-2025, abacwaningi base-University of Washington kanye naseBrigham and Women's Hospital (isibhedlela sokufundisa saseHarvard Medical School) baveze indlela engakaze ibonwe yokwelapha isifo i-Alzheimer's - ukuphefumulai-xenonigesi, engagcini nje ngokuvimbela ukuvuvukala kwe-neuroinflammation futhi inciphise ukuwohloka kobuchopho, kodwa futhi yandisa izimo zokuvikela ze-neuronal.

I-Xenonkanye nokuvikela izinzwa

Isifo i-Alzheimer's yisifo esivame kakhulu ukuwohloka kwemizwa kubantu, futhi imbangela yaso kukholakala ukuthi ihlobene nokuqongelela kwe-tau protein kanye ne-beta-amyloid protein ebuchosheni. Nakuba kube nemithi ezama ukususa lawa maprotheni anobuthi, ayizange iphumelele ekunciphiseni ukuqhubeka kwesifo. Ngakho-ke, imbangela eyinhloko yalesi sifo noma ukwelashwa akuqondwa ngokugcwele.

Izifundo zikhombisile ukuthi ukuphefumulelwai-xenoningawela umgoqo wegazi nobuchopho futhi ithuthukise kakhulu isimo samagundane anezinhlobo zesifo i-Alzheimer ngaphansi kwezimo zelebhu.Ukuhlolwa kwahlukaniswa ngamaqembu amabili, iqembu elilodwa lamagundane labonisa ukuqongelela kwamaprotheni e-tau kanti elinye iqembu laline-beta-amyloid protein accumulation. Imiphumela yokuhlolwa ibonise ukuthi i-xenon ayigcinanga nje ngokwenza amagundane asebenze kakhulu, kodwa futhi ikhuthaza impendulo yokuvikela ye-microglia, ebalulekile ekususeni amaprotheni e-tau ne-beta-amyloid.

Lokhu okutholwe okusha kuyinto entsha kakhulu, okubonisa ukuthi imiphumela yokuvikela izinzwa ingakhiqizwa ngokumane uphefumule igesi engasebenzi. Umkhawulo omkhulu emkhakheni wocwaningo kanye nokwelashwa kwe-Alzheimer ukuthi kunzima kakhulu ukuklama imithi engadlula isithiyo segazi nobuchopho, futhii-xenonangakwenza lokhu.

Ezinye izindlela zokwelapha ze-xenon

1. I-Anesthesia kanye ne-analgesia: Njengegesi efanelekile ye-anesthetic,i-xenonisetshenziswa kabanzi ngenxa yokufakwa kwayo ngokushesha kanye nokululama kwayo, ukuqina okuhle kwenhliziyo kanye nengozi ephansi yemiphumela emibi;

2. Umphumela wokuvikela izinzwa: Ngaphezu komphumela ongaba khona wokwelapha isifo i-Alzheimer esishiwo ngenhla, i-xenon iphinde yacwaningwa ukuze kuncishiswe umonakalo wobuchopho obangelwa yi-neonatal hypoxic-ischemic encephalopathy (HIE);

3. Ukufakelwa kanye nokuvikelwa kwezitho zomzimba:I-Xenonkungasiza ekuvikeleni izitho zomnikeli ekulimaleni kwe-ischemia-reperfusion, okubaluleke kakhulu ekuthuthukiseni izinga lempumelelo lokufakelwa;

4. Ukuzwela kwe-Radiotherapy: Ezinye izifundo zokuqala zikhombisile ukuthi i-xenon ingakwazi ukuthuthukisa ukuzwela kwama-tumors ekwelashweni nge-radiotherapy, okunikeza isu elisha lokwelashwa komdlavuza;